MyBioSource.com's PSMB11 Antibody (C-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunohistochemistry, and Western Blot. The PSMB11 Antibody (C-term) was generated using beta5t, and PSMB11 as the antigen and it reacts with Human.
Description
Proteasomes generate peptides that are presented by major
histocompatibility complex (MHC) I molecules to other cells of the
immune system. Proteolysis is conducted by 20S proteasomes,
complexes of 28 subunits arranged as a cylinder in 4
heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7,
and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM
600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM
600306). Three additional subunits, beta-1i (PSMB9; MIM 177045),
beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are
induced by gamma-interferon (IFNG; MIM 147570) and are
preferentially incorporated into proteasomes to make
immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit
expressed exclusively in cortical thymic epithelial cells (Murata
et al., 2007 [PubMed 17540904])